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In vitro results revealed that all the target compounds were highly effective and selective butyrylcholinesterase (BuChE) inhibitors. A small amount of organic base is added as a catalyst in the pyridine solvent, and Kneoevenagel reacts with vanillin and malonic acid to form ferulic acid. [8], Asterid eudicot plants can also produce ferulic acid. Mori H, Kawabata K, Yoshimi N, Tanaka T, Murakami T, Okada T, Murai H. Anticancer Res. The catalysts include piperidine and aniline. 2018 Oct 8;3(10):12746-12753. doi: 10.1021/acsomega.8b01953.

The structural unit containing ferulic acid in oryzanol exists in the form of ester and is easy to decompose. As a component of lignin, ferulic acid is a precursor in the manufacture of other aromatic compounds. The use of plant tissue culture is an important way to obtain ferulic acid.

Hudson EA, Dinh PA, Kokubun T, Simmonds MS, Gescher A. 2006;25 Suppl 2:91-120. doi: 10.1080/10915810600964626. Get the latest research from NIH: https://www.nih.gov/coronavirus. 2011 Mar 9;59(5):1862-70. doi: 10.1021/jf1038103. Ferulic acid is easily prepared in large quantities from rice bran pitch, a blackish brown waste oil with high viscosity, discharged in the process of the rice bran oil production. However, this method has a long reaction time of up to three weeks and is obtained as a mixture of trans and cis ferulic acid. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. [10], Ferulic acid has been identified in Chinese medicine herbs such as Angelica sinensis (female ginseng), Cimicifuga heracleifolia[11] and Ligusticum chuangxiong. There are currently not many methods for purifying ferulic acid. [17], Ferulic acid, together with dihydroferulic acid, is a component of lignocellulose, serving to crosslink the lignin and polysaccharides, thereby conferring rigidity to the cell walls.[18]. Biosynthesis is the conversion of ferulic acid precursor to ferulic acid by several microorganisms (Arthrobacter Blobiformis), such as the conversion of eugenol cinnamate extracted from clove oil to ferulic acid. Triethyl phosphite acetate and acetyl vanillin undergo a Wittig-Horner reaction in a strong base system, and acidified with concentrated hydrochloric acid to obtain ferulic acid. In plants, ferulic acid is cross-linked with polysaccharides and lignin by ester bonds or self-esterified or etherified to form diferulic acid.

In addition, activated carbon is also an excellent adsorbent material. As a building block of lignocelluloses, such as pectin[2] and lignin, ferulic acid is ubiquitous in the plant kingdom. Ferulic acid has anti-oxidation and anti-radiation properties. ACS Omega.

[6] The highest known concentration of ferulic acid glucoside has been found in flaxseed (4.1 ± 0.2 g/kg). Some studies have shown that certain plant tissue cultures can produce higher yields of ferulic acid derivatives.

2000 Nov;9(11):1163-70.

The reaction method is to hydrolyze oryzanol to prepare ferulic acid.

Optimization of acid hydrolysis conditions for feruloylated oligosaccharides from rice bran through response surface methodolgy. Amended final report on the safety assessment of Oryza Sativa (rice) Bran Oil, Oryza Sativa (rice) Germ Oil, Rice Bran Acid,Oryza Sativa (rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (rice)Bran Extract, Oryza Sativa (rice) Extract, Oryza Sativa (rice) Germ Powder, Oryza Sativa (rice) Starch, Oryza Sativa (rice) Bran, Hydrolyzed Rice Bran Extract, Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein. HHS Please enable it to take advantage of the complete set of features! J Agric Food Chem. It is also found in the tea brewed from the European centaury (Centaurium erythraea), a plant used as a medical herb in many parts of Europe. Ferulic acid can be prepared by chemical synthesis and through biological transformation. [7] It is also found in barley grain. [19] In P. fluorescens, a ferulic acid decarboxylase has been isolated. 2012 Jul;13(8):1083-8. doi: 10.2174/138945012802009008.

A small amount of organic base is added as a catalyst in the pyridine solvent, and Kneoevenagel reacts with vanillin and malonic acid to form ferulic acid. [21], It can be extracted from wheat bran and maize bran using concentrated alkali. Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells. 2012 Feb 16;5(2):236-48. doi: 10.3390/ph5020236.

Epub 2008 Sep 10. There are mainly solvent extraction methods and adsorption methods. It is an abundant phenolic phytochemical found in plant cell walls, covalently bonded as side chains to molecules such as arabinoxylans. We suggest that chemical raw materials can best be obtained from natural resources.

Int J Toxicol.  |  In wheat grain, ferulic acid is found bound to cell wall polysaccharides, allowing it to be released and absorbed in the small intestine. Ferulic acid is a hydroxycinnamic acid, an organic compound.  |  Tomaro-Duchesneau C, Saha S, Malhotra M, Coussa-Charley M, Kahouli I, Jones ML, Labbé A, Prakash S. Pharmaceuticals (Basel). Recent studies have found that most of the ferulic acid in wheat bran can be released in a relatively short period of time by increasing the extraction temperature and adding a suitable protective agent.

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