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Winter, MD, Lindsay Bazydlo, PhD, and Neil S. Harris, MD, Commission on Accreditation in Clinical Chemistry. Hemoglobin types have different electrical charges and move at different speeds. 96.5%–98.5% of total hemoglobin or 0.96–0.985 mass fraction, 1.5%–3.5% of total hemoglobin or 0.015–0.035 mass fraction, 0%–1% of total hemoglobin or 0–0.01 mass fraction. Hemoglobin A2 was not elevated. Witkowska HE, Lubin BH, Beuzard Y, Baruchel S, Esseltine DW, Vichinsky EP, et al. It’s sometimes called “hemoglobin evaluation” or “ … Attach a tube to the needle to fill it with blood. Separation of different hemoglobins is largely (but not solely) dependent on the charge of the hemoglobin molecule. I would think that in sickle cell trait there would be a roughly equal mixture of normal and mutant beta, randomly associating in hemoglobin. Your lab report should contain the range your lab uses. U.S. Hemoglobin electrophoresis was ordered because the patient had been told that he had sickle cell trait. Hemoglobin Electrophoresis Patterns in Sickle Cell Disorders (Alkaline) ... Heterozygous sickle cell trait (Hb SA) Lanes 7 and 8 (patient 3): Double heterozygous Hb SC disease (Hb SC) Lanes 9 and 10 (patient 4): Sickle cell hemoglobin with hereditary persistence of fetal hemoglobin. The normal values listed here—called a reference range—are just a guide. The anodal peak migrated in the normal location of hemoglobin A whereas the cathodal peak migrated in the normal location for hemoglobin S. Is this sickle cell trait? Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. 1. Hemoglobin types S and C mean hemoglobin S-C disease, which causes a mild or moderate form of sickle cell disease. // COVID-19: Updated Visitors Policy. This separates normal and abnormal types of hemoglobin. Complete disclaimer. This information does not replace the advice of a doctor. Washington, DC 20001 Your use of this information means that you agree to the Terms of Use. The differential diagnosis of this alkaline gel second peak are hemoglobins D, G-Philadelphia, Lepore and Korle-Bu. The expected hemoglobin electrophoresis results in blood specimens from patients with sickle cell anemia show the following values: 80% sickle cell hemoglobin (HbSS), 1% to 20% hemoglobin F (HbF), 2% to 4.5% hemoglobin A 2 (HbA 2), and absence of hemoglobin A (HbA) if the patient has not recently received a transfusion. N Engl J Med 1991; 325:1150-4. Tell your doctor if you are getting iron therapy for iron deficiency anemia. December 8, 2019, Author: Healthwise Staff Medical Review: E. Gregory Thompson MD - Internal Medicine Adam Husney MD - Family Medicine Martin J. Gabica MD - Family Medicine, Medical Review:E. Gregory Thompson MD - Internal Medicine & Adam Husney MD - Family Medicine & Martin J. Gabica MD - Family Medicine. Chernecky CC, Berger BJ (2008). This means that a value that falls outside the normal values listed here may still be normal for you or your lab. Hemoglobin electrophoresis is used as a screening test to identify normal and abnormal hemoglobins and assess their quantity. Hemoglobin D. This type of hemoglobin is present in some sickle cell disorders.  // AACC uses Cookies to ensure the best website experience. 3. Fischbach FT, Dunning MB III, eds. Reasons you may not be able to have the test or why the results may not be helpful include: If you are planning to have children and are found to have abnormal types of hemoglobin in your blood, you might consider genetic counseling. Put a gauze pad or cotton ball over the needle site as the needle is removed. Check treatment for diseases that have abnormal types of hemoglobin in the blood. © 1995-2020 Healthwise, Incorporated. But over 350 types of abnormal hemoglobin have been found. Hemoglobin electrophoresis is a blood test that measures different types of a protein called hemoglobin in your red blood cells. Case: The patient is a 30 year old male. An elastic band is wrapped around your upper arm. Hemoglobin E in low amounts means the presence of hemoglobin E trait . Masks are required throughout all facilities. Fischbach FT, Dunning MB III, eds. Having a blood transfusion in the past 3 months.

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